Table 1.
Summary of association results for 12 candidate genes on chromosome 3p.
| IBD | CD | UC | |||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Locus | SNPs tested* | Associated SNP | Screen P** | Replication P*** | Combined P** | Combined P** | Combined P** |
| MLH1 | 5/8 | - | - | - | - | - | - |
|
| |||||||
| MYD88 | 5/7 | - | - | - | - | - | - |
|
| |||||||
| LTF | 5/7 | - | - | - | - | - | - |
|
| |||||||
| GPX1 | 4/5 | rs9818758 | 0.0098 | 0.0021 | 0.00013 | 0.00065 | 0.0089 |
|
| |||||||
| rs11716445 | 0.0078 | 0.0036 | 0.00016 | 0.0054 | 0.0041 | ||
|
| |||||||
| MST1 | 3/6 | rs9858213 | 0.0046 | 3.59×10−5 | 1.48×10−6 | 6.27×10−5 | 0.0013 |
|
| |||||||
| TRIP | 5/10 | rs9858428 | 0.00092 | 0.0018 | 1.02×10−5 | 0.00055 | 0.0011 |
|
| |||||||
| GNAI2 | 8/9 | rs2298952 | 0.0044 | NR | - | - | - |
|
| |||||||
| CISH | 7/8 | - | - | - | - | - | - |
| TLR9 | 5/5 | - | - | - | - | - | - |
| PRKCD | 12/15 | - | - | - | - | - | - |
| IL17RB | 9/10 | - | - | - | - | - | - |
| IL17RD | 20/20 | - | - | - | - | - | - |
“-” results not significant at p-value threshold 0.01
*
successful SNP assays/total SNPs selected to tag locus
**
2-tailed P-values
***
1-tailed P-value NR, non replicating