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. 2015 Aug 26;10(8):e0134791. doi: 10.1371/journal.pone.0134791

Fig 2. DNMT3a expression is modulated by signaling from nerves.

Fig 2

DNMT3a expression (qPCR) in the epithelium of wounds created on the arm of axolotls that either healed without forming a blastema (lateral wound; n = 8 for day 0, 24hr, 72hr, 5 days. n = 10 for 10 days) or received a surgically deviated nerve to form an ectopic blastema (nerve deviated; n = 8 for day 0, 24hr, 72hr, 5 days. n = 10 for 10 days). In addition the nerve supply to the limb was severed proximally (denervated) prior to making wounds either with (NdevWE; n = 4) or without (LatWE; n = 4) surgically deviating a nerve distally. (* = p < 0.05; *** = p < 0.0005).