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. 2015 Aug 26;10(8):e0136304. doi: 10.1371/journal.pone.0136304

Fig 1. Effects of EP4 activation on glucose tolerance and insulin resistance.

Fig 1

Seven-week-old male db/db mice subcutaneously received either the EP4-selective agonist ONO-AE1-329 (0.3 mg/kg) or vehicle twice a day for 4 weeks. (A) Change in body weight during the study period (n = 8 each). (B) Amount of food intake (n = 8 each). (C) Results of glucose tolerance test: left, time-course of blood glucose levels; right, area under curve (AUC) (n = 7–8 each). (D) Results of insulin tolerance test: left, time-course changes of blood glucose levels; right, the inverse AUC (n = 13 each). All values are mean ± SEM. * p<0.05; ♯ p<0.01 vs. vehicle.