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. 2015 Aug 26;10(8):e0136304. doi: 10.1371/journal.pone.0136304

Fig 4. Administration of EP4 agonist alters adipose tissue macrophage polarization.

Fig 4

(A) Relative expression of marker genes for M1 (Cd11c) and M2 (MR, Cd163) macrophages in epididymal fat tissues from db/db mice administered EP4 agonist (black bar) or vehicle (white bar). All values are mean ± SEM (n = 4–5 each). ♯ p<0.01 vs. vehicle. (B) Epididymal adipose tissues of EP4 agonist–or vehicle–treated db/db mice were double stained with anti-F4/80 (green), and anti-CD11c (red, upper panel) or anti-CD163 (red, lower panel) antibodies. Arrows indicate double-positive cells. Scale bar: 100 μm. MR, Mannose Receptor.