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. 2015 May 18;29(9):3654–3667. doi: 10.1096/fj.14-266296

Figure 5.

Figure 5.

The alcohol-induced mobilization of hepatic retinoid stores can occur independent of RBP. Alcohol consumption was associated with significant increases in tissue retinol levels in both WT (n = 6–8) and Rbp−/− (n = 3–5) mice after the alcohol-adaptation period, in the (A) lung, (B) WAT, C) kidney, and (D) BAT. *P < 0.05 vs. animals of the same genotype; #P < 0.05 vs. animals consuming the same diet; 2-way ANOVA. E) Similar to WT mice, alcohol-fed Rbp−/− mice had transiently increased plasma retinol levels during the alcohol-adaptation period (n = 4 for Rbp−/− mice; WT data reproduced from Fig. 4B). A–D) *P < 0.05 vs. animals of the same genotype; #P < 0.05 vs. animals consuming the same diet; 2-way ANOVA. E) *P < 0.05 for WT mice vs. d 0; #P < 0.05 for Rbp−/− mice vs. d 0; 1-way ANOVA.