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. 2015 May 18;29(9):3654–3667. doi: 10.1096/fj.14-266296

Figure 8.

Figure 8.

The alcohol-induced depletion of hepatic retinol is blocked in Cyp2e1−/− mice, but mobilization to extrahepatic stores is preserved. A) Hepatic retinol levels decreased significantly in WT mice consuming 6.4% alcohol for 2 wk (n = 6–10), but this effect was blocked in alcohol-consuming Cyp2e1−/− mice (n = 6–11). B) Hepatic retinyl ester levels decreased in alcohol-consuming WT and Cyp2e1−/− mice, although this effect was significant only in the Cyp2e1−/− mice. The tissue retinol levels in the (C) lung, (D) WAT, (E) kidney, (F) BAT, and (G) spleen increased significantly in alcohol-consuming WT (n = 5-6) and Cyp2e1−/− (n = 5-6) mice. A, B) #P < 0.05 vs. control; 1-way ANOVA; C–G) *P < 0.05 vs. animals of the same genotype; #P < 0.05 vs. animals consuming the same diet; 2-way ANOVA.