Table 1. PICOS criteria for inclusion and exclusion of studies.

Parameter	Inclusion criteria	Exclusion criteria
Patients	Patients of any age with prostate cancer/treatment associated gynecomastia	Other types of gynecomastia
Intervention	Pharmacological, surgical or radiotherapeutic treatments
Comparator	How effective are the different treatment methods
Outcomes	Primary outcome measures: Treatment results and number of complications/side effects. Secondary outcome measures: QoL
Study design	Randomized controlled trials, non-randomized controlled trials, retrospective, prospective, or concurrent cohort studies. At least 20 patients. At least 1 year follow-up. Published in English.	Reviews, expert opinion, comments, letter to editor, case reports, studies on animals, conference reports. Less than 20 patients. Shorter follow-up than 1 year. Studies with no outcomes reported. Published before 2000. Published in any other language than English.