Table 2. Clinical and laboratory parameters of sepsis patients in “normal response to UK” group and in “low response to UK” group.
| Normal response to UK (n = 22) | Low response to UK (n = 18) | P value* | |
|---|---|---|---|
| SOFA | 5 (4–7) | 8 (6–13) | 0.03 |
| Lactate (mmol/L) | 1.0 (0.8–1.9) | 1.8 (1.2–2.7) | 0.03 |
| LDH (U/L) | 374 (252–458) | 520 (388–1071) | 0.01 |
| Creatinine (mg/dl) | 0.85 (0.7–1.2) | 1.50 (0.8–2) | 0.09 |
| Bilirubin | 0.5 (0.4–0.9) | 1.1 (0.7–1.5) | 0.02 |
| Platelet (103/mmc) | 169 (103–277) | 131 (52–178) | 0.14 |
| DIC (ISTH), N (%) | 0 | 5 (28) | 0.01 |
| DIC (JAAM), N (%) | 11 (50) | 10 (55) | 0.76 |
| MAP (mmHg) | 81 (76–90) | 78 (67–89) | 0.35 |
| Hb (g/dL) | 9.9 (9.1–12.4) | 11.1 (10.2–12.2) | 0.20 |
| SpO2 (%) | 98 (95–100) | 97 (95–99) | 0.51 |
| SvO2 (%) | 72 (67–78) | 71 (67–76) | 0.68 |
| Severe Sepsis/Septic Shock, N (%) | 14 (64)/8 (36) | 9 (50)/9 (50) | 0.52 |
| Hospital length of stay (days) | 33 (15–44) | 19.5(8–39) | 0.20 |
| Duration of mechanical ventilation (days) | 5.5 (3–14) | 4.5 (1–8) | 0.35 |
| ICU length of stay (days) | 7 (4–20) | 5 (3–9) | 0.44 |
| Mortality in ICU, N (%) | 1 (5) | 7 (39) | 0.01 |
*P value from Mann-Whitney (continuous variables) or Fisher’s exact test (categorical variables). Numbers in table refer to median (25th– 75th) or N(%). Low response to UK group is defined as those patients with UK-TEG_Ly30 value less than 64.9% (limits of normality of healthy individuals UK-TEG_Ly30 = 64.9%-100%).
Abbreviations: SOFA, Sequential Organ Failure Assessment; LDH, lactate dehydrogenase; DIC, disseminated intravascular coagulation; MAP, mean arterial pressure; Hb, hemoglobin; ScvO2, central venous oxygen saturation; SpO2, pulse oximetry.