Table 3. Coagulation and TEG parameters in healthy individuals, sepsis patients with “normal response to UK” and sepsis patients with “low response to UK”.
| Healthy Individuals | Sepsis Patients | P value* | ||
|---|---|---|---|---|
| Normal Response to UK | Low Response to UK | |||
| Coagulation Parameters | (N = 10) | (N = 22) | (N = 18) | |
| PT ratio | 1.06 (1.01–1.10) | 1.26 (1.12–1.42)^ | 1.46 (1.28–1.62)§§ | <0.001 |
| aPTT ratio | 1.04 (0.98–1.07) | 1.08 (1.01–1.26) | 1.17 (1.07–1.31) | 0.05 |
| Fibrinogen (mg/dl) | 252 (244–283) | 565 (384–682)^^ | 529 (370–749)§§ | <0.001 |
| D-dimer (ng/ml) | 78 (60–127) | 1467 (810–6170)^^ | 2250 (1182–3472)§§ | <0.001 |
| PAI-1 antigen (ng/ml) | 3.3 (1.5–5.1) | 36.1 (20–39.6)^^ | 30.7 (24.3–43.9)§§ | <0.001 |
| PAI-1 activity (ng/ml) | 0.2 (0.1–0.3) | 4.0 (0.6–5.7)^ | 3.8 (1.6–19.0)§§ | <0.001 |
| TAFI (%) | 110 (93–124) | 104 (83–130) | 111 (91–133) | 0.94 |
| TEG Parameters | (N = 40) | (N = 22) | (N = 18) | |
| TEG_r (min) | 9.1 (7.6–10.1) | 7.5 (6.1–10.5) | 11.0 (7.2–14.2) ° | 0.03 |
| TEG_angle (deg) | 55.9 (47.6–62.6) | 59.6 (48.8–68.6) | 51.3 (39.6–59.9) | 0.16 |
| TEG_MA (mm) | 61.0 (57.3–65.4) | 70.8 (66.5–77.0) ^^ | 66.9 (52.6–73.2) ° | <0.001 |
| TEG_Ly30 (%) | 1.2 (0.1–2.7) | 0.3 (0–1.4) | 0.1 (0–0.9) § | 0.02 |
| UK-TEG | ||||
| UK-TEG_r (min) | 8 (7.0–8.7) | 7.6 (5.8–10.0) | 11.3 (6.6–12.6) | 0.06 |
| UK-TEG_angle (deg) | 54.7 (37.5–65.0) | 49.4 (34.3–67.0) | 42.3 (32.8–57.3) | 0.40 |
| UK-TEG_MA (mm) | 25.2 (15.6–39.8) | 22.3 (9.4–29.0) | 53.3 (49.0–68.4) §§ °° | <0.001 |
| UK-TEG_Ly30 (%) | 91.3 (88.5–93.1) | 88.5 (76.7–92.4) | 22.9 (0–50.2) §§ °° | <0.001 |
*P value from Kruskal-Wallis rank test. Post-hoc multiple comparison analyses from Dunn’s test with Bonferroni correction,
° low responders vs normal responders p<0.05;
°° low responders vs normal responders p<0.001;
§ low responders vs healthy individuals p<0.05;
§§ low responders vs healthy individuals p<0.001;
^ normal responders vs healthy individuals p<0.05;
^^ normal responders vs healthy individuals p<0.001.
Numbers in table refer to median (25th– 75th). Low response to UK group is defined as those patients with UK-TEG_Ly30 value less than 64.9% (limits of normality of healthy individuals UK-TEG_Ly30 = 64.9%-100%).
Abbreviations: PT ratio, prothrombin time ratio; aPTT ratio, activated partial thromboplastin time ratio; PAI-1, Plasminogen Activator Inhibitor 1; TAFI, Thrombin Activatable Fibrinolysis Inhibitor; TEG, Thromboelastography; TEG_r, reaction time measured by TEG; TEG_angle, angle α measured by TEG; TEG_MA, maximum amplitude measured by TEG; TEG_Ly30, lysis at 30 minutes after MA measured by TEG; UK-TEG, urokinase kaolin activated thromboelastography, UK-TEG_r, reaction time measured by UK-TEG; UK-TEG_angle, angle α measured by UK-TEG; UK-TEG_MA, maximum amplitude measured by UK-TEG; UK-TEG_Ly30, lysis at 30 minutes after MA measured by UK-TEG.