Table 4.
Progression Rates to HGD or Cancer from Time of Intervention^
| Progressors / Non-progressors* | ||||
|---|---|---|---|---|
| Follow-up | Ablation | %# | Surveillance | %# |
| Yr 1 | 1 /32 | 3.0 | 16 / 92 | 14.8 |
| Yr 2 | 0 / 26 | 0 | 11 / 68 | 13.9 |
| Yr 3 | 0 / 21 | 0 | 2 / 56 | 3.4 |
| Yr 4 | 0 / 15 | 0 | 4 / 46 | 8.0 |
| Yr 5 | 0 / 9 | 0 | 0 / 45 | 0 |
= progressors within the yr / nonprogressors with at least that yr of follow-up
= progressors/ (nonprogressors with at least yr follow-up and progressors within that yr)
Overall progression during follow-up period was 1 IMC (2.2%) in RFA group vs. 29 HGD, 5 IMC, and 2 submucosal EAC (28.8%) in surveillance group (P <0.001). Median time from initial intervention to progression to HGD or cancer was 7.5 months in RFA and 12.5 months (IQR: 7.4, 24.2) in surveillance. Progression to HGD or cancer when stratified by center as follows: University of Pennsylvania 1/5 RFA and 19/53 surveillance, Columbia 0/10 RFA and 4/37 surveillance, Mayo Clinic 0/30 RFA and 13/35 surveillance.