Table 2.
Characteristic | SAMMPRIS Medical Group (n=227) | WASID (n=143) | p-value† |
---|---|---|---|
| |||
Age (years) | 59.5 ± 11.8 | 62.5 ± 10.0 | 0.009 |
| |||
Female Gender | 82 (36%) | 55 (38%) | 0.66 |
| |||
Black Race | 49 (22%) | 37 (26%) | 0.38 |
| |||
History of Hypertension | 203 (89%) | 109 (76%) | 0.001 |
| |||
History of Diabetes | 97 (43%) | 62 (43%) | 0.91 |
| |||
Previous or Current Smoker | 149 (66%) | 101 (71%) | 0.36 |
| |||
History of Coronary Artery Disease | 59 (26%) | 41 (29%) | 0.63 |
| |||
History of Ischemic Stroke (not the qualifying event) | 58 (26%) | 34 (24%) | 0.71 |
| |||
Not Using Statin at Enrollment | 31 (14%) | 56 (39%) | < 0.0001 |
| |||
Modified Rankin Grade ≥ 1 | 159 (70%) | 95 (66%) | 0.49 |
| |||
NIH Stroke Scale > 1 | 88 (39%) | 50 (35%) | 0.51 |
| |||
Physical Activity Out of Target‡ | 161 (71%) | 105 (73%) | 0.64 |
| |||
Old Infarcts in the Territory of the Symptomatic Artery | 75/222 (34%) | 28/130 (22%) | 0.015 |
| |||
Qualifying Event was a Stroke | 152 (67%) | 90 (63%) | 0.43 |
| |||
On Antithrombotic Therapy at Qualifying Event | 140 (62%) | 75 (52%) | 0.084 |
| |||
Time from Qualifying Event to Randomization (days) | 7 (4 – 19) | 8 (5 – 14) | 0.87 |
| |||
Symptomatic Artery | < 0.0001 | ||
Internal Carotid Artery | 49 (22%) | 26 (18%) | |
Middle Cerebral Artery | 105 (46%) | 43 (30%) | |
Vertebral Artery | 22 (10%) | 24 (17%) | |
Basilar Artery | 51 (22%) | 38 (27%) | |
Combination | 0 | 12 (8%) | |
| |||
Symptomatic Artery in Posterior Circulation | 73 (32%) | 74 (52%) | 0.0002 |
| |||
Percent Stenosis of Symptomatic Artery § | 81 ± 7 | 78 ± 7 | 0.0006 |
| |||
Categories of Percent Stenosis of Symptomatic Artery § | 0.0004 | ||
70–79% | 102 (45%) | 94 (66%) | |
80–89% | 97 (43%) | 40 (28%) | |
90–99% | 28 (12%) | 9 (7%) | |
| |||
Systolic BP (mmHg) | 146.8 ± 21.8 | 139.1 ± 17.8 | 0.0002 |
| |||
Diastolic BP (mmHg) | 82.3 ± 12.0 | 76.5 ± 9.5 | < 0.0001 |
| |||
BMI (kg/m2) | 30.7 ± 6.3 | (n=140) 29.4 ± 5.7 | 0.048 |
| |||
LDL (mg/dl) | (n=226) 97.7 ± 36.6 | (n=120) 125.4 ± 39.7 | < 0.0001 |
| |||
HDL (mg/dl) | (n=226) 38.8 ± 10.1 | (n=124) 43.8 ± 13.4 | 0.0004 |
| |||
HgbA1c (%) (For patients with a history of diabetes) | (n=91) 7.6 (6.9 – 10.2) | (n=42) 8.0 (6.5 – 10.3) | 0.89 |
Values are mean ± standard deviation or number (%) or median (inter-quartile range).
Comparisons of the baseline characteristics of the two studies were made using either an independent groups t-test (for means), Fisher’s exact test (for percentages) or the Wilcoxon rank sum test (for medians).
Physical activity was measured in the two studies as follows: SAMMPRIS used the Physician-based Assessment and Counseling for Exercise (PACE) Current Physical Activity Status Score with a score of 1–3 considered in-target. WASID used four categories (Sedentary, Minimal, Moderate, Vigorous) with Moderate or Vigorous considered in-target. (see on-line supplement for details).
Percent stenosis according to the reading of the angiogram by the study physician at the patient’s clinical site.