Table 1.
Demographic and cognitive testing within the cirrhosis group
Alcoholic Cirrhosis (n=46) | Non-Alcoholic Cirrhosis (n=102) | |
---|---|---|
Age | 53±6 | 56±8 |
Years of Education | 13±5 | 13±6 |
Gender (men/women) | 26/20 | 65/37 |
Race (Caucasian/African-American/Hispanic) | 31/10/5 | 78/21/3 |
MELD score | 15.2 ± 0.9 | 13.5 ± 0.6 |
Number (%) with prior OHE | 27 (58%) | 44 (43%)* |
Serum Sodium (mEq/L) | 135.5 ± 0.8 | 136.8 ± 0.6 |
Total bilirubin (mg/dL) | 3.0 ± 0.6 | 2.6 ± 0.3 |
INR | 1.4 ± 0.06 | 1.3 ± 0.03 |
Serum Creatinine (mg/dL) | 1.06 ±0.06 | 1.01 ± 0.07 |
Venous Ammonia | 49.9 ± 3.5 | 50.0 ± 2.9 |
Cognitive testing | ||
Number connection-A (sec) | 46.4 ± 3.2 | 42.5 ± 2.0 |
Number connection-B (sec) | 135.9 ± 16.0 | 122.5 ± 9.25 |
Inhibitory Control Lures (number) | 13.7 ± 1.4 | 11.5 ± 0.9 |
Digit Symbol (score) | 45.5 ± 2.6 | 52.1 ± 1.7 * |
Block design (score) | 21.3 ± 1.8 | 26.2 ± 1.3 * |
Line tracing time (sec) | 122.2 ± 8.6* | 118.3 ± 6.3 |
Line tracing errors (number) | 41.9 ± 4.9 | 31.57 ± 3.2 |
Serial Dotting (sec) | 90.1 ± 6.9* | 71.29 ± 3.1 |
Inhibitory Control Targets (%) | 89.8 ± 2.1 | 95.01 ± 0.61* |
p<0.05 Alc vs. Nalc, data is presented as Mean±SEM; a high score on block design, digit symbol and inhibitory control targets and a low score on the rest indicate poor cognition.
Alc: abstinent alcoholic cirrhosis, Nalc: non-alcoholic cirrhosis.