Table 5. Parameters determined from model.

Variable	Unit	Description
La = 1490	μm/s	apical membrane water permeability
Lb = 790	μm/s	basolateral membrane water permeability
$G_t^{\text{Na}}=32$	pS/μm2	maximum conductance of paracellular Na+ per unit areac,d
$G_t^{\mathrm{K}}=0.4$	pS/μm2	maximum conductance of paracellular K+ per unit aread
$G_t^{\text{Cl}}=80$	pS/μm2	maximum conductance of paracellular Cl− per unit areac,d
$G_t^{{\text{HCO}}_3}=0.8$	pS/μm2	$\text{maximum conductance of paracellular}{\text{HCO}}_3^{-}\text{per unit}{\text{area}}^{\mathrm{d}}$
$G_t^{\mathrm{H}}=1.85$	pS/μm2	maximum conductance of paracellular H+ per unit aread
GHK = 0.68	fS/μm2	maximum conductance of apical HKATPase per unit aread
GNBC = 4.54	pS/μm2	maximum conductance of NBC per unit aread
GCaKC = 313	pS/μm2	maximum conductance for CaKC per unit area
αNaK = 1.42	fmol/μm2.cycle	density of NaKATPase on basolateral membrane
αNKCC = 4.34	fmol/μm2.cycle	density of NKCC co-transporter on basolateral membrane

^cValues found to be in good comparison with predicted model values published in Warren et al. (2009).