Table 1.
Baseline characteristics and concomitant treatments in critically ill patients (N = 2213)
| Age (years) | 63 ± 16 |
| Female sex | 824 (37.3 [35.3–39.3]) |
| Reason for admission to ICU [n (%)] | |
| Medical | 962 (43.5 [41.4–45.6]) |
| Surgical | 691 (31.2 [29.3–33.1]) |
| Emergency surgical | 548 (24.8 [23.0–26.6]) |
| Main diagnosis | |
| Sepsis | 595 (27.0 [25.2–28.9]) |
| Cardiac | 454 (20.6 [18.9–22.3]) |
| Respiratory | 238 (10.8 [9.5–12.1]) |
| Neurologic | 180 (8.2 [7.1–9.3]) |
| Trauma | 141 (6.4 [5.4–7.4]) |
| Intoxication | 41 (1.9 [1.3–2.5]) |
| Other | 558 (25.3 [23.5–27.1]) |
| SOFA score | 7 [4–10] |
| Physiological variables | |
| HR (bpm) | 95 ± 24 |
| MAP (mmHg) | 70 ± 16 |
| CVP (mmHg) | 8 ± 5 |
| Urine output (ml/h) | 40 [20–80] |
| Fluid balance previous 24 h (ml) | 2698 [1500–3945] |
| Lactate (mmol/L) | 1.8 [1.1–2.9] |
| Vasopressor/inotropic agents | |
| Dopamine (n (%); μg/kg min) | 91 (4); 5 [4–10] |
| Norepinephrine (n (%); μg/kg min) | 903 (41); 0.16 [0.07–0.34] |
| Epinephrine (n (%); μg/kg min) | 74 (3); 0.1[0.03–0.30] |
| Dobutamine (n (%); μg/kg min) | 159 (7); 4 [3–5] |
| Mechanical ventilation, n (%) of 2172 | |
| None | 736 (33.8 [31.8–35.8]) |
| Noninvasive ventilation | 64 (2.9 [2.2–3.6]) |
| Invasive mechanical ventilation | 1372 (63.1 [61.1–65.1]) |
| Characteristics of patients under invasive mechanical ventilation n (%) of 1372 | |
| Sedation present | 927 (67.6 [65.1–70.1]) |
| Spontaneous ventilation included | 602 (43.8 [41.2–46.4]) |
| Renal replacement therapy, n (%) of 2087 | |
| None | 1930 (92.5 [91.4–93.6]) |
| Dialysis | 58 (2.8 [2.1–3.5]) |
| Hemofiltration | 99 (4.7 [3.8–5.6]) |
Qualitative data are given as absolute number (percentage); quantitative data are given as median value [interquartile range]
HR heart rate, MAP mean arterial pressure, CVP central venous pressure, CVVH continuous veno-venous hemofiltration