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CONSORT diagram showing the analytic cohort of 2,923 patients with tumors classified as ductal (n = 2,599) and lobular (n = 324) enrolled in the monotherapy arm of the BIG 1-98 clinical trial that compared 5 years of letrozole with 5 years of tamoxifen. ER, estrogen receptor; HER2, human epidermal growth factor receptor; PgR, progesterone receptor.
