Fig 4.

Disease-free survival and overall survival hazard ratio (HR) estimates and 95% CIs comparing the efficacy of letrozole versus tamoxifen for histologic subgroups. The results were based on multivariable models that included classic clinicopathologic variables as predictors: age, tumor size, nodal status, histologic grade, histology (ductal/lobular), local therapy, subtype (luminal A or B), and treatment. The box size is inversely proportional to the SE of the HR; the extended horizontal lines indicate the 95% CIs. (*) Treatment by histology (ductal/lobular), P = .006; treatment by subtype (LA/LB), P = .01. (†) Treatment by histology (ductal/lobular), P = .035.