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Schematic of the phopivirus genome, with predicted polyprotein cleavage sites, and sequence identities across the genome to HAV, avian encephalomyelitis virus (AEV), and seal aquamavirus A1 (SeAV-A1). The picornavirus genome consists of a single open reading frame (ORF) which produces a polyprotein that is cleaved into the structural (P1) and non-structural (P2 and P3) proteins.
