Skip to main content
. 2015 Aug 27;5:191. doi: 10.3389/fonc.2015.00191

Figure 1.

Figure 1

Medulloblastoma with myogenic features. Posterior fossa anaplastic medulloblastoma with myogenic features. (A) MRI at diagnosis showing posterior fossa mass. (B) H&E stain showing anaplastic medulloblastoma. Note the large cells with pink cytoplasm. (C) BRCA2 sequencing of peripheral blood mononuclear cells from the patient showed the wildtype nucleotide 6174T (c.5946T) on one allele (red peak), which is lost in the second allele, resulting in a G nucleotide (black peak) at the same position (arrow) and a downstream frameshift. (D) Immunohistochemistry demonstrating myogenic differentiation (cells positively staining for myogenin and desmin), as well as positive synaptophysin, and high mitotic index (Ki67).