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. Author manuscript; available in PMC: 2016 Aug 18.
Published in final edited form as: J Am Coll Cardiol. 2015 Aug 18;66(7):765–773. doi: 10.1016/j.jacc.2015.06.019

Central Illustration. Cardiac RF Control Improves Survival: Number of RFs in Control and Outcomes.

Central Illustration

The number of RFs in control is plotted against mortality (A and B) and against CVD events (C and D). In panels A and C, RFs in control are defined on the basis of the BARI 2D protocol (main analysis). A J-shape is evident: individuals with 6 RFs in control have a numerically higher risk of events than those with 5 RFs in control. In panels B and D, “optimal ranges” are defined for systolic and diastolic BP and HbA1c. A J-shape is no longer evident and the risk gradient comparing 6 versus 0 to 2 RFs in control is steeper. BP = blood pressure; CVD = cardiovascular disease; HbA1c = glycosylated hemoglobin; HR = hazard ratio; MI = myocardial infarction; RF = risk factor.