. Author manuscript; available in PMC: 2016 Aug 18.

Published in final edited form as: J Am Coll Cardiol. 2015 Aug 18;66(7):765–773. doi: 10.1016/j.jacc.2015.06.019

Table 6.

Hazard Ratios for Death and CVD Events by Number of RFs In Control/Within Target Range^*

Number of RFs In Control	Death^†			Death/MI/Stroke^†

	HR	95% CI	p Value	HR	95% CI	p Value
0–2	3.8	2.2–6.5	<0.0001	2.4	1.6–3.6	<0.0001
3	2.4	1.4–4.1	0.0009	2.0	1.3–2.8	0.00011
4	1.9	1.1–3.0	0.0142	1.6	1.1–2.3	0.0163
5	1.5	0.9–2.4	0.1365	1.4	1.0–2.1	0.0709
6	1.0	Reference	--	1.0	Reference	--
Global p value			<0.0001			0.0005

Abbreviations as in Tables 1, 2, and 5.

RFs in-control defined as: non-HDL-C <130 mg/dl, TG <150 mg/dl, 110 mm Hg< SBP < 140 mm Hg, DBP <80 mm Hg, 6.5%< HbA_1c <7.5%, nonsmoker. Note redefinition of target range for SBP and HbA_1c in this exploratory analysis

^†

Cox models adjusted for baseline number of RF in control, number of total lesions, abnormal LVEF, myocardial jeopardy index, history of prior revascularization, age, sex, race/ethnicity, country, and trial strata.