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. 2015 Jun 18;24(18):5115–5125. doi: 10.1093/hmg/ddv230

Figure 1.

Figure 1.

Biochemical and phenotypic analyses of wild-type and AAV mice. (A) Hepatic microsomal G6Pase-α activity in the AAV mice is shown at the indicated ages in weeks (W). Hepatic microsomal G6Pase-α activity in 75–90-week-old wild-type mice (n = 18) averaged 171.8 ± 7.1 nmol/min/mg (100%). (B) Blood glucose levels following a 24 h fast in 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (C) Hepatic microsomal G6P uptake activity of 75–90-week-old wild-type (n = 10), AAV (n = 8) or 6-week-old G6pc−/− (n = 6) mice. (D) Hepatic G6PT mRNA expression in 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (E) Serum metabolite profiles in 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (F) BWs of 12-week-old wild-type (n = 8) and AAV mice (n = 8) and 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (+/+), wild-type mice; (−/−), G6pc−/− mice. Data are mean ± SEM. *P < 0.05 and **P < 0.005.