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. 2015 Jun 18;24(18):5115–5125. doi: 10.1093/hmg/ddv230

Figure 2.

Figure 2.

Phenotype and insulin tolerance profiles of wild-type and AAV mice. (A) Hepatic glycogen and triglyceride contents in 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (B) Hepatic levels of pyruvate and lactate in 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (C) Twenty-four hour fasted blood insulin levels in 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (D) Insulin tolerance profiles of 12-week-old wild-type (triangle, n = 8) and AAV mice (filled triangle, n = 8), and 75–90-week-old wild-type mice (circle, n = 10) and AAV mice expressing 7–8% (square, n = 2) or 16–38% (filled square, n = 6) mice treated with 0.25 IU/kg of insulin. Values are reported as a percent of respective level of each group at zero time. (E) Body fat contents in 12-week-old wild-type (n = 8) and AAV mice (n = 8) and 75–90-week-old wild-type (n = 10) and AAV (n = 8) mice. (+/+), wild-type mice. Data are mean ± SEM. *P < 0.05 and **P < 0.005.