Table 1.
Metaphase chromosomal breakage analysis of primary fibroblasts
Sample | DEB dose (µg/ml) | Number of metaphases scored | Total number of breaks | Breaks per Cell |
---|---|---|---|---|
Fetal fibroblast 94–38 | 0 | 66 | 4 | 0.06 |
(FANCG−/−) | 0.01 | 49 | 47 | 0.96 |
0.1 | 1 | 5 | 5.00 | |
FA 100166/1 | 0 | 52 | 15 | 0.29 |
(UBE2T−/−) | 0.01 | 50 | 44 | 0.88 |
0.05 | 50 | 101 | 2.02 | |
0.1 | 50 | 140 | 2.80 | |
NL1433889 | 0 | 50 | 0 | 0.00 |
(normal control) | 0.01 | 47 | 2 | 0.04 |
0.1 | 47 | 7 | 0.15 |