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. 2015 Jun 29;24(18):5234–5249. doi: 10.1093/hmg/ddv244

Figure 2.

Figure 2.

Reduction of PGCs in Fancb mutant mice. (A–C) Immunostaining of mouse whole embryos at E9.5, E11.5 and E13.5. SOX2 is a marker for PGCs, and GATA4 is a marker for gonadal somatic cells. Scale bars: 100 µm. (D) Total numbers of the SOX2-positive PGCs per embryo at E9.5. (E) Total numbers of PGCs in each genital ridge (cells/genital ridge) at E11.5. Mean and SEM for independent mice are shown. Numbers of mice analyzed at E9.5 and E11.5, respectively: five wild-type and four Fancb mutant mice. *P < 0.05. Unpaired t-test.