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. 2015 Jun 29;24(18):5234–5249. doi: 10.1093/hmg/ddv244

Figure 5.

Figure 5.

Regulation of DDR factors on the sex chromosomes in Fancb mutant mice. (A–G and I) Immunostaining of chromosome spreads of pachytene spermatocytes. In panel G, dotted squares represent areas surrounding sex chromosomes, and the areas are magnified in the bottom panels. Arrows: sex chromosomes. Scale bars: 10 µm unless otherwise indicated. (H) Scoring of the number of RAD51 foci per X axis, Y axis, or pseudo-autosomal region (PAR) in mid-pachytene spermatocytes. Distribution of data is shown as dots; mean ± SEM for independent mice is shown as bars. Total numbers of analyzed nuclei are indicated in the panel. Four independent mice were analyzed for both wild-type and Fancb mutant mice. *P < 0.05. Unpaired t-test. (J) Model of the role of FANCB in DDR pathways on the sex chromosomes during meiosis.