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. 2015 Jun 29;24(18):5198–5210. doi: 10.1093/hmg/ddv241

Figure 4.

Figure 4.

Effect of PreP overexpression and activity on LTP impairment. LTP was recorded in hippocampal slices of the indicated Tg mice (12–13 months of age). Slices from 12 to 13 months old mAPP mice showed a reduced LTP compared with nonTg slices. MAPP/PreP slices had significantly increased LTP compared with mAPP slices (A and B). (C and D) Effect of PreP on Aβ-induced LTP decline. Hippocampal slices from the indicated Tg mice were treated with vehicle or Aβ (200 nM), and then recorded CA1 LTP for 120 min. Data are presented as mean ± SE. N = 8–12 slices per group.