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. 2015 Jun 29;24(18):5198–5210. doi: 10.1093/hmg/ddv241

Figure 5.

Figure 5.

Effect of PreP overexpression and activity on learning memory in mAPP mice. (A) Radial water maze test in the indicated Tg mice at 12–13 months of age. *P < 0.05 versus Tg mAPP or mAPP/PE mice. N = 8–10 mice per group. (B–E). Results of the MWM test showed the average latency to escape to locate the hidden platform during each day of training sessions (B), *P < 0.05 compared with Tg mAPP or Tg mAPP/PE mice, the mean number of mice crossing the target during probe trials (C), and time spent in the quadrant where the hidden platform is located (D). Tg mAPP and mAPP/PE mice showed much less preference for the target quadrant compared with nonTg mice. MAPP/PreP mice demonstrated an increase in the percentage of time spent in the target quadrant compared with mAPP or mAPP/PE mice. (E) Pattern of representative searching traces for the indicated Tg mice in search of the target. N = 8–15 mice per group.