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. 2015 Jun 29;24(18):5219–5233. doi: 10.1093/hmg/ddv243

Figure 4.

Figure 4.

Nebulin deficiency shifts myosin expression from glycolytic (IIB) to oxidative (I/IIA) types. (A) Example of typical electrophoretic pattern of whole muscle lysate from 6-month-old WT and Neb cKO mice. (Left lane is a MHC type standard, Std.) (B) MHC type composition as function of age. For simplicity sake, MHC composition of Ctrl is only shown for 5-week-old mice. (C) Change in MHC composition as function of age. In all muscle types, nebulin deficiency increases MHC type I (left top), decreases type IIB (left bottom) and increases MHC IIA(X), except for the Sol where IIA(X) goes down. (D) MHC IIB content in control muscle correlates with muscle weight in nebulin-deficient muscle (5 weeks). (See B for muscle abbreviations. Additionally: Biceps, B; Triceps medialis, Tm; Triceps lateralis, Tla; and Triceps longus,Tlo).