Figure 5.

Ultrastructural studies of EDL and Sol muscle of Ctrl and Neb cKO mice (6 months). (A) Ctrl EDL and (C) Ctrl Sol muscles show normal sarcomere structure. (B) cKO EDL and (D) cKO Sol sarcomeres have an overall normal structure, except that Z-disks tend to be wavy. (E) Densitometry of Ctrl EDL sarcomere and (F) cKO EDL sarcomere. Analyzed regions indicated by the box reveal a clear H-zone in Ctrl (see also arrow heads) but not in Neb cKO. (G–I) Rod body analysis. (G and H) Selected areas rich in rod bodies (dark elongated structures). (I) The area per rod body (left) was less in EDL than in Sol cKO muscles but the combined rod body area (expressed as fraction of fiber area) was not different (Calibration bars: 1.0 µm.).