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. 2015 Aug 27;5:13428. doi: 10.1038/srep13428

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Funnel plot asymmetry still suggests the presence of publication bias and an overestimation of the overall effect size of NOX2 in stroke. Using the trim and fill analyses, the intervention effect is adjusted for possible missing studies (filled red symbols) amongst published and present data (open symbols). Studies showing larger infarcts in NOX2 KO mice and thus a smaller or no effect of NOX2 in experimental stroke, are still missing. For further explanations see Fig. 3.