Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Aug 27;5:13545. doi: 10.1038/srep13545

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

(A) Observed (data points, n = 5) and simulated (solid lines) xenograft γH2AX biomarker kinetics following repeat dosing of AZD6738. (B) Observed (data points, n = 10) and simulated (solid lines) xenograft tumor growth following repeat dosing of AZD6738. (C) Observed (data points, n = 10) and simulated (solid lines) LoVo derived mouse xenograft tumor growth following repeat dosing of AZD6738 and 5 days of 2 Gy ionizing radiation. (D) Model simulation of tumor growth under conditions of 5 days of daily 2 Gy radiotherapy for 3 weeks in combination with varying dose of AZD6738 therapy, followed by 1 week of wash-out. Green bars indicate two sets of daily IR exposure over 5 days and the colored bar indicates the 3 weeks of AZD6738 therapy. Error bars represent standard error of the mean. QD = Once daily dosing, BD = Twice daily dosing.