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. 2015 Aug 27;5:13565. doi: 10.1038/srep13565

Figure 2. Effects of F96 on TPA induced ear edema and ear tissues levels of fatty acid ethanolamides.

Figure 2

(a) H&E-stained sections of normal mouse ear (Control), TPA-induced irritant dermatitis (Vehicle) and various doses (30, 10, 3 mg/kg) of F96 treated. (b) F96 (30, 10, 3 mg/kg) dose-dependently reduced ear weight. (c) F96 (10 mg/kg) reduced ear weigh in wild type 129 s mice but not in PPAR-α knockout mice. (d–e) F96 normalized PEA and OEA levels in a dose-dependent manner after TPA application for 3 h in C57BL/6J mice. **p < 0.01 and ***p < 0.001 vs Control vehicle-treated group. #p < 0.05, ##p < 0.01 and ###p < 0.001 vs TPA+F96-treated group. n = 8–10.