Skip to main content
. 2015 Aug 27;5:13490. doi: 10.1038/srep13490

Figure 3. DMD mice develop severe arrhythmias upon Iso challenge that are prevented by Cx43 peptide mimetic treatment.

Figure 3

(a) Representative baseline tracings of 4 month old WT, mdx, and mdx:utr whole animal ECGs following anesthesia. (b) ECG tracings after Iso challenge (5 mg/kg, IP). (c) Representative ECG tracings following treatment with Gap26 (1 μg/kg, IV) or Gap19 (10 μg/kg, IV) for 20 minutes and Iso challenge (5 mg/kg, IP). (d-e) Arrhythmia scores based on pre-determined scale where: 0 = no arrhythmias, 1 = single PVCs, 2 = double PVCs, 3 = triple PVCS or non-sustained VT, 4 = sustained VT or AV block, 5 = death. (f-g) Respective interval measurements made from randomly selected sequential beats of WT, mdx, and mdx:utr ECG tracings from baseline, +Iso challenge, and Cx43 peptide mimetic treated conditions. * = p < 0.05 compared to Baseline, ** = p < 0.05 compared to +Iso.