Table 2. Association of HNF-1B expression with clinicopathologic parameters of HCC and ICC patients.
| Variable | HCC |
P value | ICC |
P value | ||
|---|---|---|---|---|---|---|
| Low | High | Low | High | |||
| (n = 134) | (n = 49) | (n = 23) | (n = 46) | |||
| Age(yr) | ||||||
| <50 | 71 | 25 | 0.814 | 4 | 14 | 0.245 |
| ≥50 | 63 | 24 | 19 | 32 | ||
| Gender | ||||||
| Male | 118 | 50 | 0.744 | 15 | 34 | 0.453 |
| Female | 16 | 8 | 8 | 12 | ||
| Tumor size | ||||||
| <5 cm | 118 | 41 | 0.436 | 5 | 17 | 0.201 |
| ≥5 cm | 16 | 8 | 18 | 29 | ||
| Tumor number | ||||||
| Single | 64 | 25 | 0.696 | 21 | 36 | 0.178 |
| Multiple | 70 | 24 | 2 | 10 | ||
| Cirrhosis | ||||||
| No | 89 | 36 | 0.364 | 17 | 31 | 0.579 |
| Yes | 45 | 13 | 6 | 15 | ||
| HBsAg | ||||||
| Negative | 9 | 2 | 0.507 | 9 | 23 | 0.393 |
| Positive | 125 | 47 | 14 | 23 | ||
| TNM stage | ||||||
| I/II | 126 | 40 | 0.011* | 17 | 33 | 0.849 |
| III | 8 | 9 | 6 | 13 | ||
| Serum AFP | ||||||
| <400 | 87 | 29 | 0.475 | 17 | 45 | 0.007* |
| ≥400 | 47 | 20 | 6 | 1 | ||
| Histological grade | ||||||
| Well/Moderate | 103 | 30 | 0.036* | 18 | 38 | 0.663 |
| poorly | 31 | 19 | 5 | 8 | ||
| Lymphovascular invasion | ||||||
| Negative | 46 | 20 | 0.418 | 14 | 28 | 1.000 |
| positive | 88 | 29 | 9 | 18 | ||
*P < 0.05 was considered statistically significant.