Table 4. Univariate and multivariate analysis of DFS in HCC patients.

Variable	Number	Univariateanalysis	Multivariatenalysis
		P value	HR (95% CI)	P value
Histology:
Tumor HNF-1B expression
Low vs High	134 vs 49	0.021*	1.443(1.021,2.039)	0.038*
Tumor K19 expression
Low vs High	89 vs 94	0.128		NA
Tumor K7 expression
Low vs High	84 vs 99	0.051		NS
Tumor EpCAM expression
Low vs High	95 vs 88	0.684		NA
Tumor OV6 expression
Low vs High	88 vs 95	0.793		NA
Non-tumor HNF-1B expression
Low vs High	134 vs 49	0.014*		NS
Clinical characteristics
Age(yr)
<50 vs ≥50	96 vs 87	0.738		NA
Gender
Male vs Female	162 vs 21	0.695		NA
Tumor size
<5 cm vs ≥5 cm	89 vs 94	0.033*		NS
Tumor number
Single vs Multiple	159 vs 24	0.433		NA
Cirrhosis
No vs Yes	125 vs 58	0.110		NA
TNM stage
I/II vs III	166 vs 17	0.004*	1.802(1.057,3.072)	0.030*
HbsAg
Negative vs Positive	11 vs 172	0.105		NA
Serum AFP
<400 vs ≥400	116 vs 67	0.246		NA
Histological grade
Well/moderate vs poorly	133 vs 50	0.514		NA
Lymphovascular invasion
Negative vs Positive	66 vs 117	0.020*	1.460(1.057,2.017)	0.022*

NA, not adopted; NS, not significant; HR, hazard ratio; Factors with p < 0.1 in univariate analysis were adopted for further multivariate analysis. *P < 0.05 was considered statistically significant.