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. 2015 Aug 27;5:13502. doi: 10.1038/srep13502

Table 2. Logistic regression analysis for the associations of the FAM13A SNPs with COPD and LC.

SNP Frequency of genotypes
 OR (95% CI) P Frequency of genotypes OR (95% CI) P Frequency of genotypes OR (95% CI) P
Controls COPD LC COPD with LC+COPD
rs7671167
 TT 0.24 0.38 11   0.28 11   0.35 11  
 TC 0.50 0.47 0.62 [0.41–0.93] 0.0223 0.44 0.79 [0.58–1.06] 0.118 0.49 0.69 [0.49–0.98] 0.036
 CC 0.26 0.15 0.19 [0.09 –0.37] <0.00012 0.28 0.95 [0.67–1.34] 0.761 0.16 0.45 [0.29–0.70] 0.00042
 TC+CC 0.76 0.62 0.54 [0.36–0.79] 0.00152 0.72 0.84 [0.63–1.12] 0.230 0.65 0.61 [0.44–0.85] 0.0032
rs1903003
 TT 0.27 0.40 11   0.32 11   0.38 11  
 CT 0.51 0.47 0.63 [0.42–0.94] 0.024 0.46 0.77 [0.58 –1.04] 0.084 0.49 0.69 [0.49–0.96] 0.028
 CC 0.22 0.13 0.41 [0.23–0.71] 0.00142 0.22 0.85 [0.60–1.20] 0.355 0.13 0.42 [0.26–0.67] 0.00022
 CT+CC 0.73 0.60 0.56 [0.38–0.52] 0.00282 0.68 0.80 [0.61 –1.05] 0.103 0.62 0.60 [0.44–0.83] 0.00192
rs2869967
 TT 0.34 0.23 11   0.35 11   0.23 11  
 CT 0.49 0.49 1.41 [0.90–2.20] 0.134 0.43 0.86 [0.65–1.14] 0.295 0.49 1.44 [0.48–1.00] 0.052
 CC 0.17 0.28 2.41 [1.44–4.05] 0.00072 0.22 1.27 [0.89–1.81] 0.193 0.28 2.36 [1.53–3.64] <0.00012
 CT+CC 0.66 0.77 1.66 [1.09–2.53] 0.01702 0.65 0.96 [0.74–1.25] 0.782 0.77 1.67 [1.18–2.36] 0.00342

COPD—chronic obstructive pulmonary disease; LC—lung cancer; COPD with LC+COPD: the associations with COPD were studied twice: using pure COPD group and COPD with 40% admixture of subjects with concomitant LC.

1Reference category; OR (95% CI), odds ratio (95% confidence interval).

2Result statistically significant (P < 0.0125, after Bonferroni correction).