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. 2015 Aug 27;5:13502. doi: 10.1038/srep13502

Table 3. The allele frequency distribution and logistic regression analysis of the IREB2 and FAM13A SNPs in COPD and LC.

SNP Frequency of genotypes
 OR (95% CI) P Frequency of genotypes OR (95% CI) P Frequency of genotypes OR (95% CI) P
Allele Controls COPD LC COPD with LC+COPD
rs2568494
 G 0.66 0.65 11   0.60 11   0.62 11  
 A 0.34 0.35 1.04 [0.80–1.26] 0.765 0.40 1.31 [1.09–1.57] 0.00432 0.38 1.18 [0.94–1.50] 0.152
rs2656069
 A 0.76 0.68 11   0.79 11   0.80 11  
 G 0.24 0.32 0.81 [0.59–1.11] 0.178 0.21 0.82 [0.67–1.02] 0.074 0.20 0.2 [0.63–1.06] 0.126
rs10851906
 A 0.76 0.80 11   0.80 11   0.80 11  
 G 0.24 0.20 0.83 [0.60–1.13] 0.234 0.20 0.79 [0.64–0.98] 0.032 0.20 0.82 [0.63–1.07] 0.137
rs13180
 T 0.61 0.62 11   0.67 11   0.64 11  
 C 0.39 0.38 0.94 [0.72–1.22] 0.631 0.33 0.77 [0.64–0.94] 0.00642 0.36 0.89 [0.72 –1.12] 0.321
rs7671167
 T 0.49 0.61 11   0.50 11   0.59 11  
 C 0.51 0.39 0.61 [0.47–0.79] 0.00022 0.50 0.97 [0.82–1.16] 0.767 0.41 0.68 [0.54–0.84] 0.00032
rs1903003
 T 0.52 0.63 11   0.55 11   0.62 11  
 C 0.48 0.37 0.64 [0.49–0.83] 0.00092 0.45 0.91 [0.76–1.08] 0.285 0.38 0.66 [0.53–0.82] 0.00022
rs2869967
 T 0.58 0.48 11   0.56 11   0.48 11  
 C 0.42 0.52 1.55 [1.20–2.00] 0.00092 0.44 1.10 [0.91–1.30] 0.349 0.52 1.53 [1.23–1.89] 0.00012

COPD—chronic obstructive pulmonary disease; LC—lung cancer; COPD with LC+COPD: the associations with COPD were studied twice: using COPD group and COPD with 40% admixture of subjects with concomitant LC.

1Reference category; OR (95% CI), odds ratio (95% confidence interval).

2Result statistically significant (P < 0.0125, after Bonferroni correction).