Fig. 6.

Effect of NO synthase inhibition with l-NAME on mesenteric arterial contractile function. First-order mesenteric arteries were harvested from mice 6 and 24 h after injection of LPS (20 mg/kg) or saline (vehicle). Force (in mN) was measured in intact mesenteric arteries under isometric conditions on a wire myograph as described in materials and methods. A–C: dose responses to PE with and without preincubation with l-NAME (0.1 mM) in control (A), 6-h LPS-injected (B), and 24-h LPS-injected (C) mice. All data are expressed as means ± SE; n = 5–6/group.