Table 2.
si RNA inhibition of RAEC Lp and TAMRA P0
|
Control |
siRNA |
||||
|---|---|---|---|---|---|
| RAEC Parameter\Treatment | μ ± SE | n | μ ± SE | n | P Value (One Tail/Two Tails) |
| Lp, ×107 cm·s−1·mmHg−1 | 6.84 ± 0.27 | 8 | 2.98 ± 0.27 | 7 | 1.85 × 10−7 |
| TAMRA | |||||
| P0, ×105 cm/s | 1.09 ± 0.11 | 8 | 1.17 ± 0.13 | 8 | 0.35 |
| Pc, ×105 cm/s | 1.39 ± 0.12 | 8 | 1.25 ± 0.07 | 8 | 0.65 |
| Albumin | |||||
| P0, ×106 cm/s | 2.04 ± 0.40 | 13 | 1.70 ± 0.39 | 13 | 0.033/0.065 |
| Pc, ×106 cm/s | 3.74 ± 0.78 | 9 | 2.76 ± 0.73 | 9 | 0.0036/0.0072 |
| RAEC Statistical Test | Metric | ||||
| Post-to-pre-siRNA treatment ratios of Lp versus ratios of TAMRA P0 | 4.0 × 10−8 (P value by t-test) | ||||
| Bootstrap distribution on derived statistic (where a negative value indicates a significant difference; Fig. 7A) | 99% probability that μ < −0.52 | ||||
RAEC, rat aortic endothelial cell; siRNA, small interfering RNA.