TABLE III.

Clinical Characteristics of Adolescent Idiopathic Scoliosis Cases with Rare Variants in FBN1

	No Variant (N = 328)	FBN1 Variant (N = 15*)	P Value
Female patients†	277 (84%)	13 (87%)	1
Spinal curve‡	55° ± 16°	72° ± 20°	1.1 × 10−4
Height percentile‡	46 ± 30§	60 ± 32	0.15
Weight percentile‡	57 ± 31§	56 ± 32	1
First-degree relative with treated adolescent idiopathic scoliosis†	44 (13%)	2 (13%)	1
Ghent systemic features score‡ (points)	2.6 ± 1.7#	4.0 ± 2.2**	5.3 × 10−3
Beighton joint hypermobility score‡ (points)	1.5 ± 1.7††	2.5 ± 2.4**	0.05

^*One patient had two mutations.

^†The values are given as the number of patients, with the percentage in parentheses.

^‡The values are given as the mean and the standard deviation.

^§The values are based on 217 patients.

^#The values are based on 205 patients.

^**The values are based on twelve patients.

^††The values are based on 204 patients.