Table 2.
TRP channels in vascular smooth muscle
| TRP | Function | Tissue |
|---|---|---|
| TRPC1 | ROCE (ET-1 constriction), SOCE | Brain (124), aorta (344), lung (245–247) |
| TRPC3 | GPCR-mediated vasoconstriction | Brain (4, 5, 283, 398), aorta (198), heart (266), kidney (296), lung (420) |
| TRPC4 | SOCE | Aorta and mesentery (196, 197) |
| TRPC5 | SOCE | Brain (403) |
| TRPC6 | GPCR-mediated vasoconstriction, myogenic tone | Portal vein (146), aorta (323), brain (217, 387) |
| TRPV1 | Vasoconstriction | Aorta, skeletal muscle (158, 201), mesentery (273), cephalic circulation (46) |
| TRPV2 | Mechanosensitive Ca2+ influx | Aorta (238) |
| TRPV3 | mRNA present in VSM but no known function | Aorta and lung (408) |
| TRPV4 | Ca2+ influx, vasodilation | Brain (79, 221), mesentery (81) |
| TRPA1 | Vasodilation | Aorta (405) |
| TRPM4 | Depolarization, myogenic tone | Brain (64, 82, 83, 104, 114, 115, 117) |
| TRPM8 | Vasoconstriction | Aorta (151) |
| TRPP2 | Ca2+ entry, vasoconstriction, myogenic tone | Mesentery (279, 308), brain (243) |
ROCE, receptor-operated Ca2+ entry; SOCE, store-operated Ca2+ entry; ET-1, endothelin-1; GPCR, G protein-coupled receptor. Reference numbers are given in parentheses.