Figure 1.

Lethal response of different genotypes to increasing doses of TNF and generation of consomic mice

1. Mice were injected with three different doses of TNF and mortality was observed for 96 h. Ratios of deaths/total are displayed. Statistical significance of the differences in survival was calculated relative to the B group or the B.S.chr6 BB group. Student’s t-test using unpaired comparisons and two-tailed analysis. ***P < 0.001 and ****P < 0.0001.
2. Breeding scheme for the generation of B.S.chr6 consomic mice for the distal part of chr6. After N10 generations of backcrossing, an intercross was performed resulting in progenies carrying at least 40-cM-sized haplotypes of B homozygosity (black), BS heterozygosity (green) or S homozygosity (grey). The location of the Tnfrsf1a gene is indicated.