Figure 5.

Scatterplots and Spearman rank correlation analysis of T_1/2 are displayed. The T_1/2 of BAX 855 was positively correlated to preinfusion VWF antigen plasma concentrations (A) and negatively correlated with ABR (B). The T_1/2 values for these analyses were derived from PK assessments conducted in 26 subjects at their first exposure to BAX 855, using the 1-stage clotting assay. The circles represent individual subject values. An apparent outlier appears in A for a subject with a very low T_1/2 and a high ABR; it is of note that no inhibitory antibodies to FVIII were detected in this subject.