Table 3.

Summary of bleeding episodes by time after prophylactic BAX 855 infusions

Cause of bleeding episode parameter	Time since last prophylactic infusion
	≤24 h	>24 to ≤48 h	>48 to ≤72h	>72 to ≤96 h	>96 h
NA
Number of infusions in analysis	5907	5862	5763	4297	1338
Spontaneous/ unknown
Number of bleeding episodes	26	40	42	25	24
Bleeding episodes per prophylactic infusion	0.0044	0.0068	0.0073	0.0058	0.0179
Injury
Number of bleeding episodes	21	30	30	9	15
Bleeding episodes per prophylactic infusion	0.0036	0.0051	0.0052	0.0021	0.0112
All
Number of bleeding episodes	47	70	72	34	39
Bleeding episodes per prophylactic infusion	0.0080	0.0119	0.0125	0.0079	0.0291

A bleeding episode at more than 96 hours could occur only if the subject deviated from the protocol-specified infusion interval, as 96 hours was the maximum. The analysis was performed on the full analysis set, which included subjects with prophylactic infusion intervals for 5 days or longer.