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Dose Escalation Schedule of Dinaciclib
| Cohort | No Pts Treated |
Median Rx (Days) |
Maximum Rx Duration (Days) |
Pts with DLT |
Pts with TLS (Dialysis) |
No Pts with Dose Reduction |
|---|---|---|---|---|---|---|
| 5 mg/m2 | 4 | 36 | 346 | 0 | 0 | |
| 7 mg/m2 | 6 | 180 | 470 | 1 | 0 | |
| 10 mg/m2 | 3 | 232 | 345 | 0 | 1 | |
| 14 mg/m2 | 16 | 145 | 342 | 1 | 4 (1) | 5 |
| 17 mg/m2 | 4 | 148 | 309 | 2 | 1 (1) | 1 |
| 10→14 mg/m2 | 6 | 163 | 218 | - | 2 | 1 |
| 7→10→14 mg/m2 | 13 | 148 | 308 | - | 1 (1) | 1 |
Key: No-number; Pt-patients; Rx-Treatment; DLT-dose limiting toxicity; TLS-tumor lysis syndrome.
