Table 4. Primary and Secondary Outcomes.^*.

Outcome	Intensive Therapy (N = 5128)		Standard Therapy (N = 5123)		Hazard Ratio (95% CI)	P Value
	no. of patients (%)	% per yr	no. of patients (%)	% per yr
Primary outcome	352 (6.9)	2.11	371 (7.2)	2.29	0.90 (0.78–1.04)	0.16
Secondary outcome
Death
Any cause	257 (5.0)	1.41	203 (4.0)	1.14	1.22 (1.01–1.46)	0.04
Cardiovascular causes	135 (2.6)	0.79	94 (1.8)	0.56	1.35 (1.04–1.76)	0.02
Nonfatal myocardial infarction	186 (3.6)	1.11	235 (4.6)	1.45	0.76 (0.62–0.92)	0.004
Nonfatal stroke	67 (1.3)	0.39	61 (1.2)	0.37	1.06 (0.75–1.50)	0.74
Fatal or nonfatal congestive heart    failure	152 (3.0)	0.90	124 (2.4)	0.75	1.18 (0.93–1.49)	0.17
Causes of death
Any	257 (5.0)	1.41	203 (4.0)	1.14	1.22 (1.01–1.46)	0.04
Unexpected or presumed cardio-    vascular disease†	86 (1.7)		67 (1.3)
Fatal myocardial infarction†	19 (0.4)		13 (0.3)
Fatal congestive heart failure†	23 (0.4)		16 (0.3)
Fatal procedure†
For cardiovascular disease	10 (0.2)		3 (0.1)
For noncardiovascular disease	1 (<0.1)		3 (0.1)
Fatal arrhythmia†	4 (0.1)		10 (0.2)
Fatal stroke†	9 (0.2)		11 (0.2)
Other cardiovascular disease†	8 (0.2)		10 (0.2)
Cancer	65 (1.3)		63 (1.2)
Condition other than cancer or    cardiovascular disease‡	50 (1.0)		35 (0.7)
Undetermined	7 (0.1)		11 (0.2)

^*The primary outcome was the first occurrence of nonfatal myocardial infarction or nonfatal stroke or death from cardiovascular causes. Data within categories are not mutually exclusive, and patients who were classified as having more than one possible cause of death are listed in the relevant categories. Hazard ratios are for the intensive-therapy group as compared with the standard-therapy group.

^†This condition was a component of the outcome of fatal cardiovascular disease.

^‡Additional details are provided in the Supplementary Appendix.