Fig 3. APLP2 genotype and reading behaviour interact to influence refractive eye development in children.

Refractive development in ALSPAC participants (n = 5,200) was modelled over the 8–15 year age range. Models included as a predictor variable either rs188663068 genotype (A, C, D) or a binary term categorizing children as spending a “high” or “low” amount of time reading at age 8½ years (B). Analyses used the full sample (A), those with information available on time spent reading (B), or a stratified sample consisting of the low (C) or high (D) readers.