Skip to main content
. Author manuscript; available in PMC: 2015 Aug 28.
Published in final edited form as: J Gastroenterol Hepatol. 2013 Oct;28(10):1660–1668. doi: 10.1111/jgh.12291

Figure 1.

Figure 1

Histopathologic features of experimental alcohol-induced steatohepatitis—effects of myriocin treatment. Adult male Long–Evans rats were fed with isocaloric liquid diets containing 0% (control) or 37% ethanol (caloric content) for 8 weeks and were treated with vehicle or myriocin 3 times per week over the last 5 weeks of the experiment. Paraformaldehyde-fixed paraffin-embedded 5-μm-thick sections of liver were stained with HE. (a) Control livers had regular cordlike architectures and uniform hepatocyte structure. (b) Myriocin treatment had minimal discernible effect on hepatic architecture in control rats. (c) Ethanol-exposed livers exhibited foci of lymphomononuclear cell inflammation (upper left and center), apoptotic bodies, and prominent microvesicular steatosis (clear cytoplasmic vacuoles—inset). (d) Myriocin treatment nearly normalized hepatic architecture in ethanol-fed rats, although apoptosis and mild inflammation persisted (inset).