Table 1.
Timing of imaging and seizures in term asphyxiated newborns treated with hypothermia developing intraventricular hemorrhage (IVH)
| Patient # | Before or during cooling Day 1 of life | During cooling Days 2–4 of life | During rewarming Day 4 of life | After cooling and rewarming Days 4–6 of life | After cooling and rewarming Days 7–15 of life | Brain injurya | Other intracranial bleeding |
|---|---|---|---|---|---|---|---|
| Term asphyxiated newborns treated with hypothermia and developing IVH (n = 15) | |||||||
| Severity of IVH | |||||||
| IVH limited to the choroid plexus vessels in the lateral ventricles or without ventricular dilatation (n = 8) | |||||||
| 1 | HUS day 4 no IVH | MRI day 7 IVH | None | subdural hematomas | |||
| 2 | HUS day 1 no IVH | MRI day 10 IVH | CGM + WM | subdural hematomas | |||
| 3 | HUS day 3 no IVH | MRI day 10 IVH | None | subdural hematomas | |||
| 4 | HUS day 1 no IVH | MRI day 4 IVH | N/A | CGM + WM | None | ||
| 5b | HUS day 1 no IVH | HUS day 2 IVH | N/A | CGM + WM | subdural hematomas | ||
| 6 | MRI day 5 IVH | N/A | None | None | |||
| 7 | MRI day 1 no IVH | MRI day 2 IVH | MRI day 10 IVH | None | subdural hematomas | ||
| 8 | MRI day 14 IVH | None | subdural hematomas | ||||
| IVH with ventricular dilatation or parenchymal hemorrhage (n = 7) | |||||||
| 9b | seizure | HUS day 4 IVH | N/A | N/A | N/A | ||
| 10 | MRI day 3 no IVH | seizure | MRI day 13 IVH | CGM + WM + BG | subdural + epidural hematoma | ||
| 11 | MRI day 1 IVH | MRI day 2 IVH | MRI day 10 IVH | None | none | ||
| 12 | HUS day 1 no IVH | CT day 5 IVH | MRI day 10 IVH | CGM + WM | None | ||
| 13 | MRI day 3 IVH | MRI day 10 IVH | None | subdural hematomas | |||
| 14a | HUS day 1 no IVH | HUS day 2 IVH | N/A | N/A | N/A | ||
| 15 | HUS day 2 no IVH | seizure | MRI day 5 IVH | MRI day 10 IVH | CGM+WM+BG | None | |
aEach MRI or autopsy was categorized as brain injury predominantly in the basal ganglia (BG), predominantly in the watershed areas (CGM + WM), or in the cortical grey matter, white matter and basal ganglia (CGM + WM + BG)
bThese patients died from the complications of neonatal encephalopathy. Patient #5 did not have a brain MRI to define the extent of brain injury, but had an autopsy. Patients #9 and #14 did not have a brain MRI or an autopsy to define the extent of brain injury
Abbreviations: CT computed tomography, HUS head ultrasound, MRI magnetic resonance imaging, CGM cortical grey matter, WM white matter, BG basal ganglia