Table 5.

Weighted Multivariable-Adjusted Risk (Hazard Ratio (95%CI)) of CHD or Fatal CVD among WHI Participants^* Comparing RA vs. no RA

	Incident CHD		Fatal CVD
Model 1	HR (95% CI )	p-value	HR (95% CI )	p-value
RA vs. no RA	1.49 (1.20,1.86)	0.000	2.56 (1.86, 3.51)	<.0001
Age, per year	1.07 (1.07, 1.08)	<.0001	1.15 (1.14, 1.16)	<.0001
Smoking (ever vs. never)	1.25 (1.19, 1.30)	<.0001	1.44 (1.32, 1.56)	<.0001
Hypertension (yes vs. no)	1.69 (1.61, 1.77)	<.0001	1.91 (1.75, 2.09)	<.0001
Diabetes (yes vs. no)	2.42 (2.25, 2.60)	<.0001	2.49 (2.19, 2.83)	<.0001
BMI, per 1 unit	1.02 (1.02, 1.02)	<.0001	1.02 (1.01, 1.03)	<.0001
High cholesterol (yes vs. no)	1.35 (1.28, 1.44)	<.0001	0.96 (0.86,1.08)	0.541
Model 2: Adjusts for Model 1 Covariates + Joint Pain
RA vs. no RA	1.35 (1.08, 1.68)	0.009	2.41 (1.75, 3.32)	<.0001
Joint pain: Mild vs. none	1.15 (1.09, 1.22)	<.0001	0.87 (0.78, 0.96)	<.0001
Moderate vs. none	1.36 (1.27, 1.45)		1.00 (0.88, 1.13)
Severe vs. none	1.51 (1.37, 1.67)		1.38 (1.16, 1.64)
Model 3: Adjusts for Model 1 Covariates + Health Status
RA vs. no RA	1.39 (1.11, 1.73)	0.004	2.24 (1.63,3.08)	<.0001
Fair/poor health vs. other	1.58 (1.46, 1.70)	<.0001	2.22 (1.97,2.51)	<.0001
Model 4: Adjusts for Model 1 Covariates + WBC Count
RA vs. no RA	1.46 (1.17, 1.83)	0.001	2.55 (1.86, 3.51)	<.0001
Log WBC count (per SD)	1.52 (1.43, 1.62)	<.0001	1.59 (1.42, 1.78)	<.0001

^*Excluding baseline CVD or RA at follow up only. Anti-CCP=anticyclic citrullinated peptides; BMI=body mass index; CHD=coronary heart disease; CI=confidence interval; CVD=cardiovascular disease; DMARD =disease-modifying antirheumatic drugs; RA=rheumatoid arthritis; WBC=white blood cell; WHI, Women’s Health Initiative